Taranto, Circuit Judge.
Sanofi owns U.S. Patent Nos. 8,318,800 and 8,410,167, which describe and claim compositions and uses of the cardiovascular (specifically, antiarrhythmic) drug dronedarone. The '800 patent, which expires in 2019, claims pharmaceutical compositions containing dronedarone. The '167 patent, which expires in 2029, claims methods of reducing hospitalization by administering dronedarone to patients having specified characteristics. Sanofi's subsidiary, Sanofi-Aventis U.S., LLC, received approval in mid-2009 for New Drug Application No. 022425 for 400 mg tablets of dronedarone, sold as Multaq®. Both the '800 and the '167 patents are listed in the Food and Drug Administration's publication Approved Drug Products with Therapeutic Equivalence Evaluations (the "Orange Book") as patents claiming either Multaq® or a method of using Multaq®.
Watson Laboratories Inc. and Sandoz Inc., hoping to market generic versions of Multaq®, filed abbreviated new drug applications with the Food and Drug Administration. Both firms certified, under 21 U.S.C. § 355(j)(2)(A)(vii)(IV), their beliefs that the '167 and '800 patents were invalid and/or that the manufacture, use, and sale of the proposed generic drugs would not infringe either patent. Upon receiving notice of the paragraph IV certifications, the two Sanofi firms, which we will simply call "Sanofi," sued Watson and Sandoz for infringement of the two patents under 35 U.S.C. § 271(e)(2)(A).
After a three-day bench trial, the district court ruled in crucial respects for Sanofi. Sanofi v. Glenmark Pharm. Inc., USA, 204 F.Supp.3d 665, 704-705 (D. Del. 2016). As to the '167 patent, the court made the following rulings of relevance here: Sanofi proved that Watson's and Sandoz's sale of their proposed generic drugs, with their proposed labels, would induce physicians to infringe all but one of the asserted claims, id. at 673-84; and Watson and Sandoz did not prove that any of the asserted claims were invalid for obviousness, id. at 685-96. As to the '800 patent, the district court, rejecting the non-infringement argument made by Watson and Sandoz, concluded that the asserted claims do not exclude compositions containing polysorbate surfactants. Id. at 699-704. The district court then entered a final judgment rejecting the obviousness challenge to claims 1-6, 8-13, and 16 of the '167 patent; finding inducement of infringement, by both defendants, of all of those claims except claim 5; and finding infringement by both defendants of claims 1-3, 5-9, and 12-15 of the '800 patent and by Watson of claims 10 and 11 as well.
Watson and Sandoz appeal. We have jurisdiction under 28 U.S.C. § 1295(a)(1). We affirm.
I
A
In June 1998, Sanofi filed the application that established the priority date for the '800 patent on its dronedarone composition. But Sanofi did not receive FDA approval for Multaq® until mid-2009, after considerable work investigating the effects of dronedarone on heart patients. That work led to the '167 patent, which, it is undisputed here, has a priority date of February 11, 2009. J.A. 34. The prior art asserted here as a basis for invalidity of
Between November 2001 and September 2003, Sanofi conducted two materially identical large-scale clinical trials, and the methods and results were described in a 2007 publication. See Bramah N. Singh et al., Dronedarone for Maintenance of Sinus Rhythm in Atrial Fibrillation or Flutter, 357 New Eng. J. Med. 987 (2007). The EURIDIS trial drew its patients from Europe; the ADONIS trial drew its patients from North and South America, Australia, and Africa. Id. at 987. In both, dronedarone was administered to patients who were at the time in normal sinus rhythm but had earlier experienced an episode of atrial fibrillation or flutter. Id. at 988.
What was primarily being measured (the "primary end point" for which the study was designed) was simply "the time to the first recurrence of atrial fibrillation or flutter." Id. at 987; see id. at 989. The studies also were set up to record "ventricular rates during the recurrence of atrial fibrillation," id. at 990, and certain symptoms (palpitations, dizziness, fatigue, chest pain, and dyspnea) when accompanied by atrial fibrillation during monitoring, id. at 989. The 2007 Singh publication described the results regarding the issues the trials were designed to address: "dronedarone reduced the incidence of a first recurrence, as well as a symptomatic first recurrence, within 12 months after randomization" and "significantly reduced the ventricular rate during the recurrence of arrhythmia." Id. at 995.
The 2007 Singh publication also noted that, once the data from the trials was collected, the researchers conducted a "post hoc analysis" of a particular clinical-benefit issue that the trials were not designed to address: the effect of dronedarone on rates of hospitalization or death. Id. at 993. As to that issue, the 2007 publication reported: "in a post hoc analysis, dronedarone significantly reduced the rate of hospitalization or death." Id. at 995. The figures showed some differences between the two studies regarding hospitalization/death reduction, with the European trial (EURIDIS) showing greater reduction than the non-European trial (ADONIS), whereas the opposite difference existed regarding the primary measure of time to first recurrence. Id. at 993-94.
Dr. Singh and his co-author Dr. Hohnloser — the latter of whom was central to Sanofi's dronedarone studies — had already briefly reported the post-hoc analysis in public. They stated, in an abstract, that they had conducted the post-hoc analysis in order to evaluate "the potential clinical benefit of [dronedarone] at reducing hospitalization or death" and were planning a new study to assess that potential. Stefan H. Hohnloser & Bramah N. Singh, Dronedarone Significantly Decreases the Combined Endpoint of Hospitalization and Death in Patients with Atrial Fibrillation, 112 Circulation II-327, II-327-28, Abstract 1637 (2005) (Abstracts from Scientific Sessions 2005 in the Journal of the American Heart Association). In early 2006, Internal Medicine News, describing the Scientific Session presentation by Dr. Hohnloser that is apparently reflected in the 2005 abstract, noted the "potential major clinical benefit" of reduced hospitalization or death and that "Dr. Hohnloser stressed that `potential' needs to be emphasized because this was a posthoc analysis." Bruce Jancin, Dronedarone Cut Morbidity, Deaths in Atrial Fib, Internal Med. News, Mar. 15, 2006.
Meanwhile, in June 2002, even as the EURIDIS and ADONIS trials were underway, Sanofi conducted a trial to investigate safety: the ANDROMEDA trial —
In 2006, the European Medicines Agency, discussing EURIDIS and ADONIS, stated that "the clinical relevance needs further consideration." EMEA 2006 Report, at 20. It further noted that "[a] reduction in time to death and hospitalisation was noted but this reflects an ancillary analysis and needs further confirmation, in particular in the context of the negative effects seen in the ANDROMEDA." Id. at 19. The Report concluded: "At the moment, the ratio between efficacy and safety is considered negative." Id. at 24. The 2007 Tafreshi & Rowles article, for its part, stated: "The efficacy and safety of dronedarone have not yet been determined.... The existing clinical data of dronedarone, both in terms of safety and efficacy, have been confusing and severely challenged so far." Tafreshi & Rowles, at 24.
Those assessments were made while Sanofi was conducting — between June 2005 and March 2008 — the large-scale clinical trial, called ATHENA, that was designed to address the potential for clinical benefits of dronedarone that the EURIDIS/ADONIS researchers had identified in their post-hoc analysis. The results of the ATHENA study post-date the critical date of February 2008. ATHENA involved administration of dronedarone to patients who had a recent history of atrial fibrillation and/or flutter and at least one of several specified characteristics believed to be associated with cardiovascular risk. The study assessed differences in cardiovascular hospitalization or death (secondarily, in hospitalization or death regardless of cause) between patients given dronedarone and patients given a placebo. J.A. 7846-48. The study produced positive results for dronedarone. See Stefan H. Hohnloser, Effect of Dronedarone on Cardiovascular Events in Atrial Fibrillation, 360 New Eng. J. Med. 668 (2009). Those results led to the filings that resulted in the '167 patent and to the FDA's approval of Multaq®. J.A. 177 (Tr. 101), 194 (Tr. 169).
Although the pre-February 2008 prior art does not include the results of the ATHENA study, it does include an article published by Dr. Hohnloser and his colleagues in January 2008, which describes the rationale and design of the ATHENA study. Stefan H. Hohnloser, Rationale and Design of ATHENA: A Placebo-Controlled, Double-Blind, Parallel Arm Trial to Assess the Efficacy of Dronedarone 400 mg Bid for the Prevention of Cardiovascular
Id. The second part of that sentence became a centerpiece of the obviousness challenge in this case.
B
The '167 patent claims methods of reducing cardiovascular hospitalization by administering dronedarone to patients meeting conditions mirroring those stated in the in the ATHENA trial. Claim 1 is representative:
'167 patent, col. 28, line 64 through col. 29, line 15.
C
The extensive information (the "label") that Sanofi includes along with its Multaq® product — which Watson and Sandoz propose to use for their generic versions without any change material to this case, J.A. 7784, 7797-801 — relies on the key studies described above. See J.A. 7609, 7623-27. Section 1 of the label, as revised in March 2014, is titled "Indications and Usage." It provides:
J.A. 7609 (emphasis and brackets in original). That sentence says that Multaq® is indicated for use in certain patients and refers to section 14 on "Clinical Studies" for identification of those patients. Section 14 primarily describes the ATHENA study (section 14.1), but also contains a short description of the EURIDIS and ADONIS studies (section 14.2). And it refers to two studies that had to be terminated early because of negative results in their patient pools: the ANDROMEDA study (section 14.3) and the PALLAS study (section 14.4).
Both Watson and Sandoz plan to market their generic versions of Multaq® with the same labeling, including sections 1 and 14. J.A. 7643, 7784; see AstraZeneca LP v. Apotex, Inc., 633 F.3d 1042, 1045-46 (Fed. Cir. 2010) (explaining that, in general, an applicant for an abbreviated new drug application must "show that `the labeling proposed for the new drug is the same as the labeling approved for the listed drug.'" (quoting 21 U.S.C. § 355(j)(2)(A)(v))).
II
Watson and Sandoz challenge the district court's inducement finding as to the '167 patent, the district court's rejection of their obviousness challenge to that patent, and the district court's rejection of their prosecution-disclaimer argument for limiting the scope of the '800 patent claims.
A
Under 35 U.S.C. § 271(b), "[w]hoever actively induces infringement of a patent shall be liable as an infringer." Here, the district court found, the inducing act will be the marketing by Watson and Sandoz of their generic dronedarone drugs with the label described above. And the induced act will be the administration of dronedarone by medical providers to patients meeting the criteria set forth in the '167 patent claims.
"In contrast to direct infringement, liability for inducing infringement attaches only if the defendant knew of the patent and that `the induced acts constitute patent infringement.'" Commil USA, LLC v. Cisco Sys., Inc., ___ U.S. ___, 135 S.Ct. 1920, 1926, 191 L.Ed.2d 883 (2015) (quoting Global-Tech Appliances, Inc. v. SEB S.A., 563 U.S. 754, 766, 131 S.Ct. 2060, 179 L.Ed.2d 1167 (2011) (stating that "we now hold that induced infringement under § 271(b) requires knowledge that the induced acts constitute infringement")). Neither of those two knowledge requirements is disputed here. If and when Watson and Sandoz receive FDA approval and market dronedarone with the label at issue, they will know of the '167 patent (they already do) and that a medical provider's administration of the drug to the claimed class of patients is an act of infringement (which Watson and Sandoz do not dispute).
The dispute in this case involves an aspect of the connection between the marketing and the medical providers' infringement that is different from the two knowledge requirements and is inherent in the word "induce" as it has been understood in this area. The Supreme Court stated the following in Global-Tech:
563 U.S. at 760, 131 S.Ct. 2060 (brackets in original). The purposeful-causation connotation of that language is reinforced by the Court's statement: "When a person actively induces another to take some action, the inducer obviously knows the action that he or she wishes to bring about." Id.
Further reinforcement is found in the Supreme Court's discussion of inducement of copyright infringement in Metro-Goldwyn-Mayer Studios Inc. v. Grokster Ltd., 545 U.S. 913, 936-37, 125 S.Ct. 2764, 162 L.Ed.2d 781 (2005), which the Court in Global-Tech cited in discussing patent infringement, see 563 U.S. at 763, 131 S.Ct. 2060. In Grokster, the Court explained that inducement is present where "`active steps... taken to encourage direct infringement,' such as advertising an infringing use or instructing how to engage in an infringing use, show an affirmative intent that the product be used to infringe." 545 U.S. at 936, 125 S.Ct. 2764 (citation omitted). The Court cited, for support, this court's decision in Water Techs. Corp. v. Calco, Ltd., which focused on intent and noted that intent is a factual determination that may rest on circumstantial evidence. 850 F.2d 660, 668 (Fed. Cir. 1988). The Supreme Court in Grokster held: "one who distributes a device with the object of promoting its use to infringe copyright, as shown by clear expression or other affirmative steps taken to foster infringement, is liable for the resulting acts of infringement by third parties." 545 U.S. at 936-37, 125 S.Ct. 2764.
This court has accordingly explained that, for a court to find induced infringement, "[i]t must be established that the defendant possessed specific intent to encourage another's infringement." DSU Med. Corp. v. JMS Co., 471 F.3d 1293, 1306 (Fed. Cir. 2006) (en banc in relevant part) (quoting Manville Sales Corp. v. Paramount Sys., Inc., 917 F.2d 544, 553 (Fed.Cir.1990)); see ACCO Brands, Inc. v. ABA Locks Mfrs. Co., 501 F.3d 1307, 1312 (Fed. Cir. 2007). The court has articulated certain necessary conditions: the plaintiff must show "that the alleged infringer's actions induced infringing acts and that he knew or should have known his actions would induce actual infringements." DSU Med., 471 F.3d at 1306 (emphasis omitted) (quoting Manville, 917 F.2d at 553). And the court has repeatedly explained that, for the finder of fact to find the required intent to encourage, "[w]hile proof of intent is necessary, direct evidence is not required; rather, circumstantial evidence may suffice." Id. (quoting Water Techs., 850 F.2d at 668); see Ricoh Co. v. Quanta Computer Inc., 550 F.3d 1325, 1342 (Fed. Cir. 2008) (similar). When proof of intent to encourage depends on the label accompanying the marketing of a drug, "[t]he label must encourage, recommend, or promote infringement." Takeda Pharm. USA, Inc. v. West-Ward Pharm. Corp., 785 F.3d 625, 631 (Fed. Cir. 2015) (citations omitted).
In this case, the district court relied on those standards. Sanofi, 204 F.Supp.3d at 673. And, applying those standards, the court found that Sanofi had proven intentional encouragement of infringement of the independent claims. Id. at 677 ("Sanofi has proven that Defendants' proposed labels demonstrate specific intent to encourage physicians to infringe independent claims 1 and 8 of the '167 patent and will lead to such infringement...."); see id. (finding the "proposed labels encourage physicians to prescribe dronedarone to patients with at least one of the cardiovascular risk factors claimed in the '167 patent"; Watson and Sandoz "kn[o]w that their proposed labels would actually cause physicians to prescribe dronedarone to patients
We review the district court's finding of inducement based on encouragement and inferred intent for clear error. See AstraZeneca LP v. Apotex, Inc., 633 F.3d 1042, 1056 (Fed. Cir. 2010). We find no such error. The label itself has a short "Indications and Usage" section, one sentence long. It states what dronedarone is indicated for: it "is indicated to reduce the risk of hospitalization for atrial fibrillation." J.A. 7609; see J.A. 7784. And it states which patients are covered by this indication: "patients in sinus rhythm with a history of paroxysmal or persistent atrial fibrillation (AF) [see Clinical Studies (14)]." J.A. 7609; see J.A. 7784. The reference to the Clinical Studies section (14) of the label expressly directs the reader to that section for elaboration of the class of patients for whom the drug is indicated to achieve the stated objective, i.e., reduced hospitalization. Section 14 leads with and features a subsection on the ATHENA study, which sets forth the positive results, relating to reduced hospitalization, for patients having the risk factors written into the '167 patent. And it is only the ATHENA subsection — not any of the three other brief subsections — that identifies a class of patients as having been shown to achieve reduced hospitalization from use of dronedarone. The EURIDIS/ADONIS subsection says nothing about reduced hospitalization; and the ANDROMEDA and PALLAS subsections are negative warnings, describing studies that had to be terminated early because of adverse results. See J.A. 7626-27, J.A. 7800-801. The label thus directs medical providers to information identifying the desired benefit for only patients with the patent-claimed risk factors.
There was considerable testimony that this label encourages — and would be known by Watson and Sandoz to encourage — administration of the drug to those patients, thereby causing infringement. Approximately 77% of Multaq® prescriptions have actually been written for patients with the claimed risk factors. Sanofi, 204 F.Supp.3d at 677, 684; see J.A. 8069. Moreover, Dr. Kim, an expert for Sanofi, testified that a person of ordinary skill in the art would read the drug label and understand that the only FDA-approved use of dronedarone came out of the ATHENA trial, J.A. 177-79, and that a physician would find "clear encouragement" from the label to use dronedarone in a manner that infringes the '167 patent, J.A. 174, especially in light of label's description of the ANDROMEDA study, which warns of the safety concerns of using dronedarone on patients other than those for whom the ATHENA trial showed reduced hospitalization, J.A. 175-76. See also J.A. 302-304 (Dr. Reiffel, expert for Sanofi, discussing physicians' reluctance to use dronedarone in a manner that has not yet been proven successful, given the drug's poor performance in the
Watson and Sandoz contend that, because Multaq® has substantial noninfringing uses not forbidden by the proposed labels, Sanofi, 204 F.Supp.3d at 684, the district court could not permissibly find intent to encourage an infringing use. But there is no legal or logical basis for the suggested limitation on inducement. Section 271(b), on inducement, does not contain the "substantial noninfringing use" restriction of section 271(c), on contributory infringement. And the core holding of Grokster, a copyright decision that drew expressly on patent and other inducement law, is precisely that a person can be liable for inducing an infringing use of a product even if the product has substantial noninfringing uses (like the peer-to-peer software product at issue there, which was capable of infringing and non-infringing uses). 545 U.S. at 934-37, 125 S.Ct. 2764. There is no basis for a different inducement rule for drug labels.
The content of the label in this case permits the inference of specific intent to encourage the infringing use. As noted above, inducement law permits the required factual inferences about intended effects to rest on circumstantial evidence in appropriate circumstances. Moreover, in AstraZeneca v. Apotex, the court upheld an inducement finding without the kind of explicit limiting commands that Watson and Sandoz suggest a label must contain. 633 F.3d at 1058-60. In Eli Lilly & Co. v. Teva Parenteral Medicines, Inc., the court stated that "[d]epending on the clarity of the [drug label's] instructions, the decision to continue seeking FDA approval of those instructions may be sufficient evidence of specific intent to induce infringement." 845 F.3d 1357, 1368-69 (Fed. Cir. 2017) (internal citations omitted). Unlike in Takeda, the inference in the present case is based on interpreting the label's express statement of indications of use and the internally referred-to elaboration of those indications. See 785 F.3d 625. And this case is not like Vita-Mix Corp v. Basic Holding, Inc., in which the defendant, in its (non-pharmaceutical) product instructions, encouraged a noninfringing use in a way that showed an intent to discourage infringement. 581 F.3d 1317, 1328-29 (Fed. Cir. 2009). The evidence in this case supports the finding of intentional encouragement of infringing use and, therefore, of inducement.
B
Obviousness under 35 U.S.C. § 103 is a question of law based on underlying questions of fact. Allergan, Inc. v. Sandoz Inc., 726 F.3d 1286, 1290 (Fed. Cir. 2013).
Watson and Sandoz initially argue that the district court committed legal error by applying too high a standard for proving a reasonable expectation of success. We disagree.
The district court held that the claims of the '167 patent were not proved to be obvious based on its factual finding that, in light of all the evidence, "a [person of ordinary skill in the art] in 2008 would not have had a reasonable expectation that dronedarone would reduce the risk of cardiovascular hospitalization and hospitalization for [atrial fibrillation] in patients with paroxysmal or persistent [atrial fibrillation] and the associated risk factors of the ATHENA patient population." Sanofi, 204 F.Supp.3d at 691. In making that finding, the court invoked the language of "reasonable expectation" repeatedly. Id. at 686, 687, 688, 689, 691, 693, 696, 696 n.7; see also id. at 693 (crediting Sanofi's expert testimony that the EURIDIS/ADONIS post-hoc analysis did not support "any sort of scientifically reasonable likelihood that dronedarone would successfully reduce the risk of cardiovascular hospitalization in patients with persistent or paroxysmal [atrial fibrillation] and the associated risk factors").
Contrary to the contention of Watson and Sandoz, the court did not expressly or by necessary implication demand known certainty as to the objective of reduced hospitalization. No such demand is implicit in the court's finding that the Hohnloser 2008 "it is expected" statement was not a "concrete" factual assertion, id. at 688, 692, but instead a mere "hypothesis," id. at 688, 692. Nor did the court demand certainty when it simply described the proposed information for ATHENA enrollees as presenting the EURIDIS/ADONIS data "in less than certain terms," id. at 693, as one piece of evidence supporting the court's determination to credit Sanofi's expert testimony that there was no "scientifically reasonable likelihood" of the claimed hospitalization reduction based on the EURIDIS/ADONIS post-hoc analysis, id. Watson and Sandoz have not shown that the court demanded some degree of or foundation for the required expectation that is contrary to any refinement we have adopted to elaborate on the "reasonable expectation" standard. The court used and applied the terminology from our decisions that Watson and Sandoz accept.
Watson and Sandoz's appeal on obviousness thus ultimately rests on the contention that the district court's finding under the standard was clearly erroneous. We conclude that it was not. Although the evidence might well have supported the opposite finding, we cannot conclude that the district court clearly erred in its finding that Watson and Sandoz did not carry their burden of showing that a person of ordinary skill in the art in February 2008 would have had a reasonable expectation that dronedarone would succeed in reducing cardiovascular hospitalization in the ATHENA patient population.
In light of that body of publications, Watson and Sandoz relied heavily on the final publication of relevance, the January 2008 article by Dr. Hohnloser and his colleagues, in which they described the benefit of reduced hospitalization as "expected." Hohnloser 2008 at 72 ("it is expected that treatment with this compound will result in a significant reduction in the need of rehospitalizations for cardiovascular reasons"). But there was an evidentiary dispute about how that statement would be understood by a person of ordinary skill in the art.
Watson and Sandoz also point to the post-hoc analysis based on the EURIDIS and ADONIS trials. But the district court did not clearly err in finding that a relevant skilled artisan would not have relied on that analysis to form a reasonable expectation of reduced hospitalizations in the claimed populations. Sanofi, 204 F.Supp.3d at 690-91. The record contains evidence about the unreliability of post-hoc analyses generally. Rothwell, Subgroup Analysis in Randomised Controlled Trials: Importance, Indications, and Interpretation (2006) (explaining that "[p]ost hoc observations are not automatically invalid ... but they should be regarded as unreliable unless they can be replicated"). And Sanofi's
Finally, Watson and Sandoz presented evidence that Sanofi sent to some hospitals that participated in the ATHENA trial a document called "Written Subject Information," proposed to be given to ATHENA enrollees, that contained predictions about the benefits of dronedarone. J.A. 7444 (JTX-55, proposed Written Subject Information, containing the language, "it is expected, that dronedarone improves the outcome in atrial fibrillation and atrial flutter patients by reducing the admissions to hospital and by prolonging the time in normal heart rhythm"); J.A. 7977 (DTX-24, same). But there was no evidence that the documents containing "it is expected" language were ever actually given to patients in the ATHENA trial.
C
In seeking to reverse the finding of infringement of the '800 patent, Watson and Sandoz raise just one issue. They argue that the district court erred by failing to limit the claims of the '800 patent to exclude polysorbate surfactants. They point to the fact that, while prosecuting the parent application, which issued as U.S. Patent No. 7,323,493, Sanofi amended the sole independent claims (hence all claims) so as expressly to exclude pharmaceutical compositions with a "polysorbate surfactant" from the claims of the '493 patent. Based on that amendment, Watson and Sandoz contend that Sanofi made a "prosecution disclaimer" that also limits the scope of the claims of the '800 patent, despite the absence of any limiting language in the '800 patent's claims. We review the district court's rejection of this prosecution-disclaimer argument de novo. Shire Dev., LLC v. Watson Pharms., Inc., 787 F.3d 1359, 1365 (Fed. Cir. 2015). We agree with the district court.
A prosecution disclaimer occurs "when a patentee, either through argument or amendment, surrenders claim scope during the course of prosecution." Heuft Systemtechnik GmbH v. Indus. Dynamics Co., Ltd., 282 Fed.Appx. 836, 839 (Fed. Cir. 2008). But "[w]hen the purported disclaimers are directed to specific claim terms that have been omitted or materially altered in subsequent applications (rather than to the invention itself), those disclaimers do not apply." Saunders Grp., Inc. v. Comfortrac, Inc., 492 F.3d 1326, 1333 (Fed. Cir. 2007). "In general, a prosecution disclaimer will only apply to a subsequent patent if that patent contains the same claim limitation as its predecessor." Regents of Univ. of Minn. v. AGA Med. Corp., 717 F.3d 929, 943 (Fed Cir. 2013).
In this case, all that Sanofi did, in prosecuting the application that issued as the '493 patent, was to write an express limitation into the claims: "provided that the pharmaceutical composition does not contain a polysorbate surfactant." See Sanofi, 204 F.Supp.3d at 701. That language does not appear in the '800 patent claims at issue. As the district court noted, Sanofi did not argue during prosecution that the unamended claim language of the '493 patent, or the disclosed invention generally, excluded polysorbate surfactants. Id. at 702-03. In these circumstances, the process in this case fit a familiar pattern: an applicant adopts an explicit claim-narrowing limitation to achieve immediate issuance of a patent containing the narrowed claims and postpones to the prosecution of a continuation application further arguments about claims that lack the narrowing limitation. Without more than exists here, that process does not imply a disclaimer as to claims, when later issued in the continuation, that lack the first patent's express narrowing limitation.
We therefore affirm the district court's ruling that the scope of the claims of the '800 patent should not be limited so as to exclude polysorbate surfactants.
For the foregoing reasons, we affirm the district court's judgment.
Comment
User Comments