PROST, Circuit Judge.
Novo Nordisk A/S and Novo Nordisk Inc. ("Novo") appeal a decision of the United States District Court for the Eastern District of Michigan which held that claim 4 of U.S. Patent No. 6,677,358 ("'358 patent") was invalid as obvious and that the '358 patent was unenforceable due to inequitable conduct. See Novo Nordisk A/S v. Caraco Pharm. Labs.,
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