872 F.3d 1367 (2017)

AMGEN INC., Amgen Manufacturing Limited, Amgen USA, Inc., Plaintiffs-Appellees v. SANOFI, Aventisub LLC, Regeneron Pharmaceuticals Inc., Sanofi-Aventis U.S., LLC, Defendants-Appellants.

United States Court of Appeals, Federal Circuit.

Decided: October 5, 2017.

Attorney(s) appearing for the Case

DARYL JOSEFFER , King & Spalding LLP, Washington, DC, argued for plaintiffs-appellees. Also represented by CHRISTOPHER ROBERT HEALY , JOSHUA NATHANIEL MITCHELL ; MERRITT ELLEN McALISTER , Atlanta, GA; KATHERINE NICOLE CLOUSE , SARAH CHAPIN COLUMBIA , McDermott, Will & Emery LLP, Boston, MA; WILLIAM G. GAEDE, III , Menlo Park, CA; ERIC W. HAGEN , Los Angeles, CA; Emily Curtis Johnson , ERICA S. OLSON , DENNIS J. SMITH , STEVEN D. TANG , STUART L. WATT , WENDY A. WHITEFORD , Amgen Inc., Thousand Oaks, CA; CHRISTOPHER MEAD , London & Mead, Washington, DC; MELANIE K. SHARP , Young, Conaway, Stargatt & Taylor LLP, Wilmington, DE.

PAUL D. CLEMENT , Kirkland & Ellis LLP, Washington, DC, argued for defendants-appellants. Also represented by GEORGE W. HICKS, JR. , NATHAN S. MAMMEN ; SIEW YEN CHONG , VISHAL C. GUPTA , JOHN J. MOLENDA , Steptoe & Johnson, LLP, New York, NY; RICHARD PRASEUTH , Los Angeles, CA; KILEY ANN WHITE , Washington, DC.

DUANE CHRISTOPHER MARKS , Eli Lilly and Company, Indianapolis, IN, for amicus curiae Eli Lilly and Company. Also represented by GREGORY ALAN COX , GILBERT VOY , ALEXANDER WILSON .

BARBARA ANNE JONES , AARP Foundation Litigation, Pasadena, CA, for amici curiae AARP and AARP Foundation.

DIMITRIOS T. DRIVAS , White & Case LLP, New York, NY, for amicus curiae Pfizer Inc. Also represented by ERIC M. MAJCHRZAK , AMIT THAKORE ; JEFFREY NEIL MYERS , Pfizer Inc., New York, NY.

DAVID A. KELLY , Hunton & Williams LLP, Atlanta, GA, for amicus curiae Ipsen Pharma S.A.S.

MELISSA ARBUS SHERRY , Latham & Watkins LLP, Washington, DC, for amicus curiae AbbVie Inc. Also represented by MICHAEL A. MORIN , EMILY K. SAUTER .

WILLIAM MARSILLO , Boies, Schiller & Flexner, LLP, Armonk, NY, for amici curiae Luis Aparicio, M.D., W. Ross Davis, M.D., Avichai Eres, M.D., Norman Lepor, M.D., Mary McGowan, M.D., Narendra Singh, M.D., Paul Thompson, M.D., Rosa DeBernardo, Alina Wilson. Also represented by MICHAEL JAY , Santa Monica, CA.

Before Prost, Chief Judge, Taranto and Hughes, Circuit Judges.

Appellants Sanofi, Aventisub LLC, Regeneron Pharmaceuticals Inc., and Sanofi-Aventis U.S., LLC (collectively, "Appellants") appeal from a final judgment of the district court holding U.S. Patent Nos. 8,829,165 ("'165 patent") and 8,859,741 ("'741 patent") not invalid and granting a permanent injunction enjoining sales of Appellants...

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